Hepatic artery infusion (HAI) chemotherapy

About this approach

HAI delivers chemotherapy into the hepatic artery, often through an implanted pump, to expose liver tumors to a high local drug concentration. It is used by specialized multidisciplinary programs for selected colorectal liver metastases and some primary liver or bile-duct cancers, usually as one part of a larger treatment plan.

Where it fits: Regional chemotherapy for selected cancers involving the liver

Where this treatment is used

HAI has an established role at experienced centers in selected patients, but indications, drug regimens, and combinations vary. It may support tumor shrinkage, liver control, or surgery in carefully chosen cases. Published results from high-volume programs may not transfer automatically to every hospital or patient.

Procedure and practical considerations

Pump placement requires surgery and ongoing refills and monitoring. Complications can include infection, pump or catheter problems, stomach or bowel injury, liver toxicity, bile-duct injury, and systemic chemotherapy effects. Access to urgent pump expertise matters when a patient travels.

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