Bone health and skeletal-event prevention

About this approach

Cancer, bone metastases, hormonal therapy, steroids, chemotherapy, and radiation can weaken bone. Bone-health care may include fracture-risk assessment, bone-density testing, exercise and nutrition guidance, fall prevention, calcium or vitamin D review, and medicines such as bisphosphonates or denosumab when appropriate.

Where it fits: Prevention and treatment of bone loss and complications from bone metastases

Where this treatment is used

Bone-modifying medicines can reduce fractures and other skeletal complications in selected patients with multiple myeloma or solid tumors that have spread to bone. They are also used in some treatment-related bone-loss settings. The medicine, dose, schedule, kidney function, dental health, and cancer context matter.

Procedure and practical considerations

Low calcium, kidney problems, flu-like symptoms, atypical fractures, and osteonecrosis of the jaw are among the possible risks, depending on the medicine. Dental assessment and good oral care may be advised. New severe back pain, weakness, or bladder or bowel changes can signal spinal cord compression and require emergency assessment.

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Clinics reporting this approach

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