Isolated limb perfusion or infusion

About this approach

Isolated limb perfusion and isolated limb infusion temporarily separate blood flow in an affected arm or leg so a high concentration of chemotherapy can treat tumors in that limb. The techniques differ in circulation method and intensity and are available at specialized centers.

Where it fits: Regional chemotherapy for selected melanoma or sarcoma in an arm or leg

Where this treatment is used

These regional treatments may be considered for selected in-transit melanoma or unresectable sarcoma confined mainly to a limb. Their goal is local or regional control and limb preservation; they do not treat cancer elsewhere in the body. Surgery, systemic therapy, radiation, or other local treatments may be alternatives.

Procedure and practical considerations

Swelling, pain, skin or tissue injury, nerve damage, blood clots, infection, loss of limb function, and leakage of chemotherapy into the general circulation are possible. Severe toxicity can rarely threaten the limb. Specialized monitoring and rehabilitation may be required.

Cancer guides that discuss this treatment

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Clinics reporting this approach

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