About this approach
PIPAC delivers chemotherapy as a pressurized aerosol into the abdominal cavity during laparoscopy. Researchers are studying it for peritoneal metastases from ovarian, colorectal, stomach, pancreatic, and other cancers. It is different from HIPEC and standard intravenous chemotherapy.
Where it fits: Investigational regional chemotherapy for cancers spread in the abdomen
Where this treatment is used
PIPAC remains investigational in many countries and cancer settings. Early studies examine feasibility, symptoms, tumor response, and combinations, while randomized evidence and long-term survival data are still developing.
Procedure and practical considerations
The procedure requires anesthesia and repeated laparoscopy. Risks include pain, nausea, bleeding, infection, bowel or organ injury, adhesions, inability to safely enter the abdomen, and chemotherapy exposure. Travel for repeated procedures can complicate care coordination.
Clinics reporting this approach
These clinic profiles mention this approach in their published materials. Open a profile to compare locations, services, practical details, and ways to get started.
Sources
Source information checked: 2026-10-07. The links below identify the public and clinic-provided materials used for this page.
Compiled by: Cancer Clinic Finder Editorial Team
- ClinicalTrials.gov: PIPAC study listing ↗Checked 2026-10-07
- NCI: PIPAC working-group background ↗Checked 2026-10-07
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